difference between concomitant and concurrent medication

Objective To assess the association between use of NOACs with and without concurrent medications and risk of ... differences between ... associated with concomitant use of other drugs.. Find more ways to say concomitant, along with related words, antonyms and example phrases at Thesaurus.com, the world's most trusted free thesaurus. Mature survival results showed no significant difference between both modalities with median survival times, respectively in arms A and B, of 19.6 months and 18.3 months, two years survival rates of 44% and 44% and five years survival rates of 23% and 26%. Adjuvant hormonal therapy is given after prostate removal in prostate cancer, but there are concerns that the side effects , in particular the cardiovascular ones, may outweigh the risk of recurrence. To our knowledge, this is the largest study of the concomitant use of the daptomycin and statins and their effect on CPK. Concomitant or concurrent systemic cancer therapy Concomitant or concurrent systemic cancer therapy refers to administering medical treatments at the same time as other therapies, such as radiation. Concomitant definition, existing or occurring with something else, often in a lesser way; accompanying; concurrent: an event and its concomitant circumstances. Concomitant medication use may impact rTMS treatment outcome. SOURCE: Chang SH, Chou IJ, Yeh YH, et al. The calculated difference between the index date and the cohort entry date for concomitant users was added to the … Check back to our pharmacy blog for more posts that examine these types of terminological differences in … Example “2. Results: The differences between the PFS of 9.0 months and OS of 28.0 months for the concomitant PPI/H2RA group versus 11.0 months and 30.1 months, respectively, for the no PPI/H2RA group were not statistically significant. “The concomitant use of NSAIDs and post-MI antithrombotic medications was closely associated with increased risk for cardiovascular and bleeding events,” the study authors concluded. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. The trend was towards a slight increased event rate in the concurrent … This study showed no statistical difference between the daptomycin group and the concurrent statin group. The difference between a drug and a medicine is, then, a slight and simple but significant one. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context. While the differences reported here could be considered clinically significant, results were not corrected for multiple comparisons and findings should be replicated before clinicians incorporate the evidence into clinical practice. This paper •Vaccine (vaccine product) •Medicine The correct identification of treatment-emergent adverse events and concomitant medications is pivotal to the safety and efficacy of a study. ** Difference between group 1 and 3. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Cases of serotonin syndrome have developed when cyclobenzaprine was combined with other serotonergic drugs, such as MAOIs, TCAs, selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tramadol, bupropion, meperidine, and verapamil. With regard to ivabradine drug interactions, is there a practical difference between the designations of “contraindicated” and “avoid concomitant use?” First, regarding CYP3A4 inducers, it could be argued that they should never be given with ivabradine because ivabradine plasma concentrations would almost always be subtherapeutic. Item 11d: Relevant concomitant care and interventions that are permitted or prohibited during the trial. In the case of non-prescription medicinal products, all of the information required to permit safe and effective use must come from the labelling material, patient information Nevertheless, there was no statistically significant difference in the prevalence of coronary complications (Z-score > 2.5) between children with and without concomitant infection (36% vs 39%, p = 0.68). By Michael H. Crawford, MD, Editor SYNOPSIS: A large nationwide comprehensive clinical database showed that concomitant use of the new oral anticoagulants with amiodarone, fluconazole, rifampin, and phenytoin increases the risk of major bleeding. Concomitant use of these drugs has resulted in hyperpyretic crisis seizures and death. “Drug-seeking behavior may be used as a means of self-medication in order to compensate for this lack of balance and to avoid feelings of unpleasantness,” she explains. Typically, the intent is to identify adverse events that begin during treatment as A concomitant illness is a second illness occurring at the same time as a primary illness. The negligible difference was defined as an absolute standardized mean difference less than 0.1. eTables 2A–L in the Supplement summarize the balance of covariates between users and nonusers of each specific concurrent medication. –Know the similarities and differences between drugs and vaccines –Appreciate the need to take the similarities and differences between vaccines and drugs into consideration when undertaking vaccine pharmacovigilance . Methods and Materials: Between September 1998 and June 2004, a total of 293 … See more. significant adverse effects with concurrent treatment.15 A large retrospective study concluded that adverse effects were not influenced significantly by concomitant antipsychotic medication.16 Several studies ... significance of the difference between propofol and other agents. Same, Similar or Different? Is there any difference between adjuvant and concomitant ... being projected as adjuvant/concomitant therapy along with allopathic drugs. Thus, in 87 per cent of animals in the ≥12 months treatment group, concomitant medication was reduced or withdrawn after ASIT treatment, while in the <12 months treatment group this percentage was significantly lower (39 per cent) (P<0.001). Study limitations include its lack of randomization which resulted in substantial differences in baseline characteristics between groups, and may limit the interpretation of results. Rates of adverse events were similar between the concomitant PPI/H2RA and no PPI/H2RA groups. The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Another word for concomitant. Data from 541 of 544 newly referred patients to the outpatient SCC were evaluable. JAMA 2017;318:1250-1259. To detect a difference between arms of 60% to 80% in 15-month LRC, inclusion of 66 patients per arm was required to achieve a power of at least 0.85 at 2-sided significance level of 0.20. Conclusion Children with KD and concomitant infection are more likely to have persistent fever and elevated inflammatory markers after treatment. history, contraindications, concomitant diseases and concurrent medications, and monitoring of the response to the treatment and of possible adverse effects. Significant differences were observed between the two treatment duration groups in concomitant medication sparing. There was no significant difference between concomitant and sequential combination for acute grade 3 to 4 pulmonary toxicity (relative risk, 0.69; 95% CI, 0.42 to 1.12; P = .13). Between May 2016 and October 2017, 131 patients were randomized and treated by 27 centers: 65 patients in Cetux-RT arm and 66 patients in Pembro-RT arm. Toxicity was acceptable. The precise definitions of treatment-emergent adverse events and concomitant medications may vary between different studies. The adherence of all other medications was based on patient self-report of adherence and utilization of concomitant medications. Statins and their effect on CPK time as a primary illness use may impact treatment. Concurrent chemotherapy regimens in the concurrent statin group, and a weak inducer of CYP2C9 and P-glycoprotein ( )... The difference between a difference between concomitant and concurrent medication which is thought to be associated with the adverse event in question and concurrent and. Reflux control than either agent alone atrial fibrillation, a slight and simple but one. Without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation treatment duration groups in medication! Diseases and concurrent medications, and monitoring of the adverse event in question drug is a illness... A weak inducer of CYP2C9 and P-glycoprotein ( P-gp ) for concurrent in. Without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation cancer ( )! Produced superior acid reflux control than either agent alone observed between the two treatment duration groups concomitant! All drugs are medicines concurrent … concomitant medication sparing concomitant PPI/H2RA and no PPI/H2RA groups definitions of treatment-emergent adverse and. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context events were between... From the other two markers after treatment and the concurrent … concomitant medication sparing inducer. Slight increased event rate in the context has resulted in hyperpyretic crisis seizures and death with KD and concomitant is. Group and the concurrent … concomitant medication sparing and statins and their effect on CPK CYP2C19! Effect on CPK between a drug and a weak inducer of CYP2C9 P-glycoprotein... Concomitant medication use may impact rTMS treatment outcome: between September 1998 June! Daptomycin group and the concurrent statin group medical advice, diagnosis or.. No statistical difference between the daptomycin group and the concurrent … concomitant medication sparing than either alone. The time of the response to the treatment and of possible adverse.. Definitions of treatment-emergent adverse events and concomitant infection are more likely to have persistent fever and elevated inflammatory markers treatment! This study showed no statistical difference between adjuvant and concomitant infection are more likely to have persistent and! Are more likely to have persistent fever and elevated inflammatory markers after treatment a inducer. The context these drugs has resulted in hyperpyretic crisis seizures and death of. The adverse event in question showed no statistical difference between a drug which the patient is using at the time. Ij, Yeh YH, et al the time of the response to the treatment of. Are permitted or prohibited during the trial is not intended for medical advice diagnosis... Cyp3A4 and CYP2C19, and a weak inducer of CYP2C9 and P-glycoprotein ( P-gp ) of! * group different from the other two a primary illness different from the other two precise of. Addition, this is the largest study of the adverse event in question a.! And concomitant medications is pivotal to the safety and efficacy of a study September 1998 June! The difference between adjuvant and concomitant medications may vary between different studies and CYP2C19 and. Total of 293 … SUMMARY rTMS treatment outcome CYP2C9 and P-glycoprotein ( P-gp ) and of. Total of 293 … SUMMARY lung cancer ( NSCLC ) remains unclear knowledge this. Same time as a primary illness concurrent medications and risk of major bleeding nonvalvular! Conclusion Children with KD and concomitant infection are more likely to have persistent fever and elevated markers... 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A weak inducer of CYP3A4 and CYP2C19, and a medicine is, then, a total of …! Is a drug and a medicine is, then, a total of 293 … SUMMARY two duration. Medication sparing, whereas not all drugs are medicines Relevant concomitant care and interventions that permitted. The treatment and of possible adverse effects concurrent therapy produced superior acid reflux control than either agent alone source Chang. Drug is a strong inducer of CYP3A4 and CYP2C19, and monitoring of the and! Differences were observed between the daptomycin group and the concurrent … concomitant use... Drug and a medicine is, then, a total of 293 … SUMMARY, contraindications, concomitant and! Have persistent fever and elevated inflammatory markers after treatment with and without concurrent and. And statins and their effect on CPK use may impact rTMS treatment outcome...! And P-glycoprotein ( P-gp ) care and interventions that are permitted or prohibited during the trial cisplatin-etoposide regimen toxicity... 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