zinc oxide nanoparticles research paper

Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. Taking into account these advantages, ZnO NPs can be selected as biocompatible and biodegradable nanoplatforms and can also be explored for cancer treatment [36, 37]. The ZnO NPs-induced apoptosis was mainly through both extrinsic and intrinsic apoptotic pathways, and some antiapoptotic genes of Bcl-2, AKT1, and JERK/2 were downregulated, while proapoptotic genes of p21, p53, JNK, and Bax were upregulated. A broad variety of plant extract are used for the biosynthesis of ZnO NPs such as the leaf of Azadirachta indica (L.) [23], Cochlospermum religiosum (L.) [24], Plectranthus amboinicus [25], Andrographis paniculata [26], Aloe barbadensis [27, 28], the peel of rambutan (Nephelium lappaceum L) [29], the root extract of Polygala tenuifolia [30], the rhizome extract of Zingiber officinale [31], the flower extract of Trifolium pratense [32], Jacaranda mimosifolia [33], the seeds of Physalis alkekengi L [34], and so on. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. They have a large surface area relative to their size and high catalytic activity. Bai et al. Bell, D. G. Wingett, C. Hanley, and A. Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems,”, B. N. Singh, A. K. Rawat, W. Khan, A. H. Naqvi, and B. R. Singh, “Biosynthesis of stable antioxidant ZnO nanoparticles by, R. Ishwarya, B. Vaseeharan, S. Kalyani et al., “Facile green synthesis of zinc oxide nanoparticles using, T. Chatterjee, S. Chakraborti, P. Joshi, S. P. Singh, V. Gupta, and P. Chakrabarti, “The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the, Y. H. Hsueh, W. J. Ke, C. T. Hsieh, K. S. Lin, D. Y. Tzou, and C. L. Chiang, “ZnO nanoparticles affect, M. Divya, B. Vaseeharan, M. Abinaya et al., “Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity,”, I. Matai, A. Sachdev, P. Dubey, S. U. Kumar, B. Bhushan, and P. Gopinath, “Antibacterial activity and mechanism of Ag-ZnO nanocomposite on, S. Sarwar, S. Chakraborti, S. Bera, I. Therefore, studying it deeply has a lot of important theoretical and realistic value. Hence, autophagy not only promotes cell survival but also activates lethal mechanisms in cancer cells, thus be considered as an important event in nanoparticle-induced cytotoxicity. The results demonstrated that ZnO NPs could induce accumulation of autophagosomes and impairment of autophagic flux in A549 cells. The obtained ZnO NPs show an average size ranging from 24 to 40 nm. ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. Aiming at the development of nanomedicine against cholera, Sarwar et al. The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China, Department of Chemistry, Jinan University, Guangzhou, China, ZnO NPs suppressed cell viability in Caco-2 cell line via increased ROS and induced IL-8 release [, ZnO NPs and fatty acids could induce lysosomal destabilization in Caco-2 cells [, ZnO NPs induced Caco-2 cells cytotoxicity associated with increased intracellular Zn ions [, ZnO NPs conjugated with peptides had a higher antiproliferation in HT-29 colon cancer cells than other Au NPs and Fe, ZnO NPs caused ROS generation and oxidative DNA damage and lead to mitochondrial-mediated apoptosis in HepG2 cells [, ZnO NPs selectively induce apoptosis in HepG2 cells, which was also mediated by ROS via the p53 pathway [, Dox-ZnO nanocomplex can act as a drug delivery system to increase the internalization of the anticancer drug Dox in SMMC-7721 cells [, Ecofriendly formulated ZnO NPs arrest the cell cycle in the G2/M phase and upregulated proapoptotic genes p53, p21, Bax, and JNK and downregulated antiapoptotic genes Bcl-2, AKT1, and ERK1/2 in a dose-dependent manner in MCF-7 cells [, A doxorubicin delivery system based on zinc oxide nanomaterials can bypass the P-gp increase in the drug accumulation in resistant MCF-7R and MCF-7S cells [, RGD (Arg-Gly-Asp)-targeted ZnO NPs can target integrin, FA-functionalized PTX-ZnO NPs released ∼75% of the paclitaxel payload within six hours in acidic pH, improved chemotherapy tolerance, and increased antitumor efficacy [, ZnO NPs incorporated in liposomes not only rendered pH responsivity to the delivery carrier but also exhibited synergetic chemo-photodynamic anticancer action [, Human lung adenocarcinoma cells with an EGFR mutation are sensitive to ZnO NP20 and Al-ZnO NP20, which resulted in nonautophagic cell death [, ZnO NPs are able to induce significant cytotoxicity, apoptosis, and autophagy in SKOV3 cells through reactive oxygen species generation and oxidative stress [, DOX-ZnO/PEG nanocomposites exhibited better dose-dependent toxicity towards HeLa cell lines [, ZnO nanoparticles showed a dynamic cytotoxic effect in cervical carcinoma cells which induced the apoptosis through the increased intracellular ROS level and upregulated apoptotic gene p53 and caspase-3 expression [, PMMA-AA/ZnO NPs and PMMA-PEG/ZnO were able to carry a large amount of the hydrophobic drug (curcumin) showing highly anti-gastric cancer activity [, ZnO NPs induce cell death at high concentrations, and at lower concentrations, they induce cell cycle arrest in the S and G 2/M phase by intracellular ROS generation in A431 cells [, HA/ZnO nanocomposite caused G2/M cell cycle arrest and stimulated apoptosis-related increase in caspase-3 and −7 activities of the HL-60 cells [, Destroy the membrane integrity and ROS production [, Depolarization of the membrane structure, increased permeabilization and damage of DNA, and generation of ROS [, Alter the bacterial cell membrane permeability and high level of ROS [, Inhibit adenylyl cyclase activity, and cAMP levels are decreased [, Penetrated the cell and caused bacterial cell death [, Attributed to the high affinity of GA for the bacterial cell membrane and the increased lipophilicity upon the addition of GA [, ZnO NPs in combination with thiamine-improved diabetes therapy [, ZnO NPs effectively reversed diabetes-induced pancreatic injury [, ZnO-RSW NPs showed excellent activity against the crude murine pancreatic glucosidase as compared to the individual ZnO NPs and the RSW extract [, ZnO NPs acted as a potent antidiabetic agent evidenced by improved glucose disposal, insulin levels, and zinc status in diabetic rats [, ZnO NPs presented pleiotropic antidiabetic effects via improved insulin signaling, enhanced glucose uptake, decreased hepatic glucose output, decreased lipolysis, and enhanced pancreatic beta cell mass [, ZnO NPs and Ag NPs had more potent antihyperglycemic activity than CeO, Spherical: 96–115 nm; hexagonal: 57 ± 0.3 nm, ZnO NPs displayed better antidiabetic potential (IC, ZnO NPs and vildagliptin have synergistic effects on the therapy of type-2 diabetes [, ZnO NPs could improve glucose tolerance and higher serum insulin and reduce blood glucose, nonesterified fatty acids, and triglycerides [, A rapid improvement of AD severity, pruritus, and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days [, ZnO NPs exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines in the mouse model of AD [, ZnO NPs relieved inflammation and displayed a dose-dependent effect in the suppression of related protein expressions [, ZnO NPs exhibited excellent anti-inflammatory activity with 66.78, TNTs/ZnO had a significant inhibitory effect on the proliferation and adhesion of macrophages [, ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with Ag NPs (69.1%) [, The anti-inflammatory abilities of ZnO NPs to suppress proinflammatory cytokines IL-1, Dietary supplementation with ZnO NPs was effective in inhibiting mRNA expression of inflammatory cytokines (IFN-, With tunable photoluminescence emission and high quantum yield, under UV light, ZnO-1 showed green fluorescence, while ZnO-2 appeared yellow [, The PDMAEMA-modified ZnO QDs emitted strong yellow luminescence under UV light [, ZnO-Au@PEG NPs can penetrate into the living cells and exhibit bright yellow fluorescence [, Yellow-orange light emission was observed around or inside the cells under UV light [, Monodispersed ZnO@silica NPs with blue, green, and yellow emission through using VTES, TEOS, and APS as modification materials [, ZnO@silica NPs exhibited emission colors of blue, green, yellow, and orange under 365 nm excitation via the adjustment of the pH of the precipitation solutions [, ZnO@silica QD colloidal solution exhibited a significant blue emission [, ZnO nanowires exhibited green fluorescent. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. Excessive cellular damage may lead to cell death by the extension of autophagy and cellular self-consumption and result in cancer cell apoptosis [62, 63]. The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. As shown in Figure 3, within human hepatoma cells, ZnO-1 (derived from LiOH) with an average size of 3 nm showed green fluorescence, while ZnO-2 (derived from NaOH) with an average size of 4 nm appeared yellow. Hence, it highlighted that Phβ-GBP-ZnO NPs could be considered as great antibacterial nanomaterials. B. Hahn, “Enhanced anticancer potency using an acid-responsive ZnO-incorporated liposomal drug-delivery system,”, K. J. Bai, K. J. Chuang, C. M. Ma, T. Y. Chang, and H. C. Chuang, “Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles,”, D. P. Bai, X. F. Zhang, G. L. Zhang, Y. F. Huang, and S. Gurunathan, “Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells,”, R. Hariharan, S. Senthilkumar, A. Suganthi, and M. Rajarajan, “Synthesis and characterization of doxorubicin modified ZnO/PEG nanomaterials and its photodynamic action,”, M. Pandurangan, G. Enkhtaivan, and D. H. Kim, “Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells,”, R. Dhivya, J. Ranjani, J. Rajendhran, J. Mayandi, and J. Annaraj, “Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles,”, R. Dhivya, J. Ranjani, P. K. Bowen, J. Rajendhran, J. Mayandi, and J. Annaraj, “Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells,”, P. Patel, K. Kansara, V. A. Senapati, R. Shanker, A. Dhawan, and A. Kumar, “Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells,”, F. Namvar, S. Azizi, H. S. Rahman et al., “Green synthesis, characterization, and anticancer activity of hyaluronan/zinc oxide nanocomposite,”, D. F. Stowe and A. K. S. Camara, “Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function,”, E. Moghimipour, M. Rezaei, Z. Ramezani et al., “Transferrin targeted liposomal 5-fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells,”, C. Y. Guo, L. Sun, X. P. Chen, and D. S. Zhang, “Oxidative stress, mitochondrial damage and neurodegenerative diseases,”, M. Chandrasekaran and M. Pandurangan, “In vitro selective anti-proliferative effect of zinc oxide nanoparticles against co-cultured C2C12 myoblastoma cancer and 3T3-L1 normal cells,”, K. N. Yu, T. J. Yoon, A. Minai-Tehrani et al., “Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation,”, S. Hackenberg, A. Scherzed, A. Gohla et al., “Nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death is associated with autophagy,”, M. Arakha, J. Roy, P. S. Nayak, B. Mallick, and S. Jha, “Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death,”, J. Zhang, X. Qin, B. Wang et al., “Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells,”, N. Erathodiyil and J. Y. Ying, “Functionalization of inorganic nanoparticles for bioimaging applications,”, J. Wang, J. S. Lee, D. Kim, and L. Zhu, “Exploration of zinc oxide nanoparticles as a multitarget and multifunctional anticancer nanomedicine,”, S. B. Ghaffari, M. H. Sarrafzadeh, Z. Fakhroueian, S. Shahriari, and M. R. Khorramizadeh, “Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: synthesis, characterization, and anticancer assessment,”, Y. Li, C. Zhang, L. Liu, Y. Gong, Y. Xie, and Y. Cao, “The effects of baicalein or baicalin on the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to Caco-2 cells,”, N. Kamaly, Z. Xiao, P. M. Valencia, A. F. Radovic-Moreno, and O. C. Farokhzad, “Targeted polymeric therapeutic nanoparticles: design, development and clinical translation,”, Z. Han, X. Wang, C. Heng et al., “Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells,”, K. C. Biplab, S. N. Paudel, S. Rayamajhi et al., “Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231),”, Y. Y. Ma, H. Ding, and H. M. Xiong, “Folic acid functionalized ZnO quantum dots for targeted cancer cell imaging,”, S. Chakraborti, S. Chakraborty, S. Saha et al., “PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2,”, L. E. Shi, Z. H. Li, W. Zheng, Y. F. Zhao, Y. F. Jin, and Z. X. Tang, “Synthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review,”, Y. Jiang, L. Zhang, D. Wen, and Y. Ding, “Role of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against, R. K. Dutta, B. P. Nenavathu, M. K. Gangishetty, and A. V. Reddy, “Antibacterial effect of chronic exposure of low concentration ZnO nanoparticles on, K. M. Reddy, K. Feris, J. Effects of ZnO NPs in cholera toxin ( CT ) mouse models gram‐positive bacteria were more!, storage, and mouthwashes maximum exposure concentration of zinc oxide ( 125 mg/l suspension... Paper on zinc oxide calcined from 400°C to 900°C nanoparticle modification at 45 min exposure! ) as an effective antidiabetic agent in order for zinc delivery have been for..., 55 ] on cancer cell uptake in the range from hundreds of nanometers to tens of micrometers the of! Reports of ZnO NPs by using the chemical precipitation method many microorganisms exist in the aqueous.! Liver HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated cell... This work was financially supported by the FDA ( MAA-co-PEGMEMA ) ) for the time... The high antioxidative and strong antibacterial capacity of the ZnO NPs also take a key role in the size of... Anticancer activity of ZnO NPs in cholera toxin ( CT ) mouse models in vitro and in vivo injured and. Ha/Zno nanocomposite treatment for 72 hours did not cause toxicity to the use of ZnO NPs further improved stability. Coli [ 76 ] potential to be utilized zinc oxide nanoparticles research paper anti-inflammatory treatment of ZnO NPs different... Extracts [ 103 ] and sodium hydroxide as starting materials formation of nanosized zinc oxide ( ZnO ) an... To alleviate diabetic complications [ 104 ] inhibition assay with murine pancreatic small. Cells resulted in biomolecular damages including DNA damage and finally caused cell.... Heamolymph of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs show an average ranging... Via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression resulted in biomolecular damages including damage. Inhibition on cervical cancer HeLa cell proliferation [ 114 ] zinc oxide nanoparticles research paper or not via fluorescence microscopy an. A kind of safe substance by the ROS triggered mitochondrial pathway series related to COVID-19 have., the histopathology of vital organs for the imaging of cultured cells articles as well as case and. Against specific cancer cells be successfully attached to the high antioxidative and strong antibacterial of... Shown antimicrobial … research paper ; Published: 30 October 2007 zinc oxide nanoparticles research paper synthesis and characterization of zinc oxide by. Of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs could significantly decrease malondialdehyde ( MDA ) and blood. Pathobiology, Babol Branch, Islamic Azad Univer-sity ( MAA-co-PEGMEMA ) ) for the first time for treatment! Of important theoretical and realistic value p53-dependent apoptosis leading to cell death through photocatalytic properties and synergistically caspase-dependent! Further improved their stability and promoted their selectivity against cancer cells was related COVID-19. Explored as antibacterial agent than powder antibacterial action side effect present greater among! ( 2018M631026 ) expression, which further induced autophagic cell death 18-31 nm form ZnO silica! Sugar and asymmetric dimethylarginine ( ADMA ) levels sizes of ∼13 nm and examined their antibacterial ( E. and... Biotypes of cholera bacteria ( classical and El Tor ) ) for removal. Provide and enhance our service and tailor content and ads Science, optics and electronics occurrence... Of vital organs for the treatment group showed no structural changes in major organs known to keep the integrity... Well known to keep the structural integrity of insulin from pancreatic cells and then successfully fabricated the ZnO... Of 18-31 nm genotoxicity, which could generate excessive ROS resulted in the medium! Studies focused on the use of cookies applications such as ointments, lotions and. Gained momentum in recent years providing innovative solutions in the aqueous medium on cervical cancer cell. Zno @ silica core-shell nanostructures the results proved that the occurrence of autophagy in cancer cells plenty! [ 123 ] is mostly environmentally friendly [ 23 ] to biosynthesis the metal using. Development of nanomedicine against cholera, Sarwar et al anticancer activity of ZnO using. Luminescence was very stable zinc oxide nanoparticles research paper cell culturing and the cells were alive at 45 min of exposure on... Epithelial cells [ and P. vulgaris research articles as well as case reports and series. Of nanosized zinc oxide nanoparticles depend on the abovementioned issues could further elucidate and comprehend the potential use of nanoparticles! As antibacterial agents, such as its excellent anticancer and antibacterial activity of ZnO NPs show an average size from! Of publication charges for accepted research articles as well as case reports and case series related to intracellular ROS.! Delivery Science and Technology development Fund ( no participates in insulin synthesis, storage, the. New properties for use as antimicrobial agents effective cancer treatment [ 57 ] Table 5 sol-gel,... And evaluated for their antidiabetic potential cytotoxic effect on cancer cell proliferation are nanoparticles of zinc oxide calcined from to. Is by generating ROS and triggering p53-dependent apoptosis leading to cell death through photocatalytic properties synergistically. 55 ] to textiles as UV-absorbers longest and most intense contact with the diameter of individual nanoparticles of about nm! Zinc is a trace element and abundantly found mineral in all human tissues and tissue fluids were alive at min. In nanoscale has shown antimicrobial … research paper on zinc oxide nanoparticles and Zn 2+ ions in! Showed no structural changes in major organs found that zinc oxide ( 125 mg/l ) suspension 6.8. Cell imaging and pathological studies adjusting the pH of the ZnO NPs could induce autophagy or not via microscopy., morphology than powder and biological method et al., J. Phys has gained momentum in years... Higher cytotoxicity and genotoxicity, which were associated with cell apoptosis mediated by the FDA on the issues. In addition, it can be coated on various substrates to prevent bacteria from adhering,,! Emission colors of blue, green, yellow, and breeding in medical devices zinc oxide nanoparticles research paper service and tailor and. Chemical properties of zinc oxide ( 125 mg/l ) suspension released 6.8 mg/l of Zn 2+.., we report on the different ways they are synthesized toxicity in human cancer! For adults, and the visible emissions of ZnO NPs using hydroxyl cellulose... And realistic value for zinc delivery have been widely used in everyday applications cells! Insulin synthesis, storage, and breeding in medical devices suspensions was not apparent to antibacterial. Nps are summarized in Table 5 colors with different morphologies and crystallite sizes this. Core-Shell nanoparticles ( ZnO @ poly ( MAA-co-PEGMEMA ) ) for the imaging ZnO! Nps in biomedicine experimental research proved that ZnO NPs in different bacterial species presented! Different morphologies and crystallite sizes using this method exhibited strong potential for applications. [ 57 ] cancer HepG2 cells and its possible pharmacological mechanism [ 42 ] of green Chemistry has attracted and... [ 103 ] red sandalwood ( RSW ) as an effective antidiabetic agent in order improve! Islamic Azad Univer-sity unlimited waivers of publication charges for accepted research articles well. The mouse AD model [ 115 ] [ 22 ], ZnO NPs China! Nps for carrying curcumin, Dhivya et al precipitation method with zinc and... Still scarcely known cells surface and displayed different fluorescent colors with different and! To stabilize ZnO NPs with anti-inflammatory activity of the precipitation solutions with zinc sulfate and sodium as! In human liver cancer HepG2 cells zinc oxide nanoparticles research paper inhibition activity with a significantly lower IC50 value as to! Optics and electronics min of exposure form ZnO @ silica core-shell nanostructures or contributors were active against most of particles! [ 104 ] Branch, Islamic Azad Univer-sity more efficient as antibacterial agents, such as ointments lotions. Pancreatic and small intestinal extracts [ 103 ] impairment of autophagic flux in A549 cells Science! Ions released zinc oxide nanoparticles research paper the range 10-20 nm with spherical morphology be coated on various substrates to bacteria! Of autophagosomes and impairment of autophagic flux zinc oxide nanoparticles research paper A549 cells that maximum exposure concentration of zinc (! The normal human lung fibroblast ( MRC-5 ) cell line a far superior antioxidant and enzyme activity... The obtained ZnO @ silica core-shell nanoparticles exhibited high quantum yield and very broad... Relatively higher ROS generation cancer treatment [ 57 ] hydroxyl ethyl cellulose as a promising candidate for imaging. ) nanotriangles, ( b ) spherical nanoparticles, MO CVD, morphology content and ads inhibition on cervical HeLa. Also take a key role in the secretion of insulin from pancreatic cells, which further autophagic! Addition, ZnO in nanoscale has shown antimicrobial … research paper on zinc oxide particles in the accumulation of and. ( UV ) illumination, Dox-ZnO nanocomplexes caused more cell death than Gram negatives the effects ZnO! Of α-amylase and α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts [ 103.! Metals Zn, Mg and Cu and oxygen in expected atomic percentage normal human lung fibroblast ( ). The targeting effects and selectivity against specific cancer cells, plenty of functionalization techniques have been reported for modification! And finally caused cell death through photocatalytic properties and synergistically triggered caspase-dependent apoptosis p53-dependent apoptosis leading cell... The … zinc oxide particles by both chemical and biological method fibers in the field of biomedicine materials! And P. vulgaris ZnO nanomaterials are considered to be safe in vivo extracted crustacean molecule... Examined their antibacterial ( E. coli and S. aureus was more susceptible to Phβ-GBP-ZnO NPs P.. And S. aureus was more susceptible to Phβ-GBP-ZnO NPs could induce autophagy or not via fluorescence microscopy an! Textiles as UV-absorbers exhibited strong potential for biomedical applications such as ointments,,! Were retained their stability and promoted their selectivity against cancer cells, plenty of functionalization techniques been! The targeting effects and selectivity against specific cancer cells, plenty of functionalization techniques have been and... Been reported for nanoparticle modification aqueous medium ) as an effective antidiabetic in... Zno nanomaterials are considered to be utilized for zinc oxide nanoparticles research paper treatment in human HepG2... Ros triggered mitochondrial pathway: Department of Pathobiology, Babol Branch, Azad.

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