concomitant vs concurrent chemotherapy

In … The addition of concurrent chemotherapy to RT in patients with high-risk major SGCs did not offer an advantage in OS. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. Start a 14-Day Trial for You and Your Team. every week. We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + … Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India . ... 30 Baas P, Belderbos JSA, Senan S, et al. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. Require these words, in this exact order. discover and read the research Bourhis J, Sire C, Graff P, et al. A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma. Evidence suggests that concurrent treatments may be more effective than sequential ones for some types of cancer, and have led to revisions in treatment recommendations. The study from Duke University compared hyperfractionated radiotherapy (125 rad [1.25 Gy] twice per day) with and without concurrent platinum-based chemotherapy and demonstrated improved local control (55% vs 34%) and a trend toward improved survival at 3 years. To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one. Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies. Published by Elsevier Inc. All rights reserved. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). concurrent ifosfamide was 10.2 g/m2. advanced squamous cell carcinoma of the head and neck. Patients who received concurrent chemotherapy were of younger age (mean age 60.5 years vs 62.9 years; P < 0.001), ... As in many clinical situations, the absolute benefit of concomitant chemotherapy will be driven in large part by the absolute risk of recurrence and death in the patient population being treated. Conclusion:This combined chemoradiotherapy approach is safe and efficacious for advanced unresectable head and neck cancer. 15,000 peer-reviewed journals. Concurrent chemotherapy is medication provided alongside radiation therapy for cancer patients. Adjuvant hormonal therapy is given after prostate removal in prostate cancer, but there are concerns that the side effects , in particular the cardiovascular ones, may outweigh the risk of recurrence. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. However, around one-third of the patients cannot complete cisplatin because of toxicity. Significant toxicity (47%) in HU arm. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Sakvajoli JV, Morioka H, Trippe N, Kowalski LP. We'll do our best to fix them. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context. https://doi.org/10.1053/ajot.2000.0210306. Look in other contemporaneous works to see whether that idea was common then. Read and print from thousands of top scholarly journals. Concomitant or concurrent systemic cancer therapy Concomitant or concurrent systemic cancer therapy refers to administering medical treatments at the same time as other therapies, such as radiation. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India Komaki R, Seiferheld W, Curran W, et al. No major late toxicity was seen. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. vs 1.6 yrs. Reset filters. All the latest content is available, no embargo periods. Journal Article. The main acute toxicities were hematologic toxicity, esophagitis, and alopecia. The hazard of accelerated tumor clonogen repopulation during radiotherapy, Feasibility of curative radiotherapy with a concomitant boost technique in 33 patients with nonsmall cell lung cancer (NSCLC), Schuster-Uitterhoeve, ALJ; Hulshof, MCCM; Gonzales, DG; Koolen, M; Sminia, P, Phase I/II study of treatment of locally advanced (T3/T4) non-oat cell lung cancer with concomitant boost radiotherapy by the Radiation Therapy Oncology Group (RTOG 83-12): long-term results, Graham, MV; Pajak, TE; Herskovic, AM; Emami, B; Perez, CA, High-dose, hyperfractionated, accelerated radiotherapy using a concurrent boost for the treatment of nonsmall cell lung cancer: unusual toxicity and promising early results, Concomitant boost radiation therapy for inoperable non-small cell lung cancer: Preliminary report of a prospective randomized study, Paclitaxel as a radiation sensitizer in non-small cell lung cancer, Preliminary analysis of a phase II study of weekly paclitaxel and concurrent radiation therapy for locally advanced non-small cell lung cancer, Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC), Nonparametric estimation from incomplete observations, N2 (clinical) non-small cell carcinoma of the lung: prospective trials of radiation therapy with total doses 60 Gy by the Radiation Therapy Oncology Group, Induction cisplatin/vinblastine and irradiation in unresectable squamous cell lung cancer: failure patterns by cell type in RTOG 88-08/ECOG 4588, Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer, Management of unresectable stage III non-small-cell lung cancer. Seven hundred sixteen patients were included in this trial. Eur Arch Otorhinolarygol 1992; 249:211–215. The concurrent chemotherapy consisted Conclusions: Long-term results of this schedule are encouraging However. The median and 1-yr progression-free survival rates were 9.0 mo and 27.8%, respectively. Hematologic toxicities and alopecia were the major acute toxicities during induction chemotherapy; 8.7% of the patients experienced grade 3–4 neutropenia and alopecia. Acute confluent mucositis (Radiation Therapy Oncology [RTOG] grade 3) developed in 50% of patients, but there was no severe long-term treatment-related toxicity. Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. What is known about tumour proliferation rates to choose between accelerated fraction or hyperfraction? Table 1. Bookmark this article. over 18 million articles from more than 1995 Kragujevac - Jeremic I PMID 7844608-- "Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer." The use of induction chemotherapy has been explored as a strategy to address distant treatment failures. §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. – Springer Journals. Radiotherapy commenced on d 49 and was delivered with accelerated fractionation with concomitant boost at 1.8 Gy/fraction/d, 5 d/week and 1.5 Gy/fraction/d to a boost field as a second daily treatment for the last 10 treatment days to 60 Gy/35 fractions/5 wk. Published. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. However, PCI was delivered more frequently for the sequential group. A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. Concurrent chemotherapy in 1980s Studies Stages Arms Results Hreschyshyn et al (1979)1 GOG 04 IIIB-IVA RT alone vs RT + HU Superiority in DFS and OS rates in RT+ HU arm. Overall survival at 2 years, 3 years, and 5 years were 58.7%, 52.8%, and 42.4%, respectively. We therefore performed a retrospective ana-lysis in a mono-institutional group with newly diagnosed Do not surround your terms in double-quotes ("") in this field. The multivariate analysis showed that complete response to treatment was the only significant factor for OS. Search All patients with Ewing sarcoma or rhabdomyosarcoma received addi-tional concurrent chemotherapy, including vincristine (n 5 15 patients), etoposide (n 5 9 patients), cyclo-phosphamide (n 5 1 patient), and/or dactinomycin (n 5 1 patient). This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. However, around one-third of the patients cannot complete cisplatin because of toxicity. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial. 16. Purpose: The previous individual patient data meta-analyses of chemotherapy in locally advanced non-small-cell lung cancer (NSCLC) showed that adding sequential or concomitant chemotherapy to radiotherapy improved survival. Overall response rate to the treatment was 65.2%. Enjoy affordable access to This patient with concomitant rectal cancer refused further chest radiation after 20 Gy of a planned 60 Gy. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309) (Abstract) Proc Am Soc Clin Oncol. 169 pts. Saunders Company. Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … The concurrent chemotherapy regimen was cisplatin (40 mg/m2/week). Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. Neither PFS, cancer-free survival nor OS was statistically significantly improved in the chemotherapy arm at the time of reporting (median follow-up not stated), although there is a trend in favour of the chemotherapy [five year PFS 61% with RT vs. 74% with CT-RT: p = 0.10, five year OS 73% with RT versus 78% with CT-RT, p = 0.41]. As nouns the difference between concurrent and concomitant is that concurrent is one who, or that which, concurs; a joint or contributory cause while concomitant is something happening or existing at the same time. Our experience suggests that concurrent chemotherapy and concomitant boost radiotherapy approaches appear promising. Background We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. The role of combined chemoradiation, Experience with dose escalating using CHARTWEL (continuous, hyperfractionated, accelerated radiotherapy weekend less) in non-small-cell lung cancer, A Radiation Therapy Oncology Group (RTOG) phase III radnomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, Twice weekly paclitaxel and radiation for stage III non-small-cell lung cancer, Preliminary analysis of a phase II study of paclitaxel and CHART in locally advanced non-small cell lung cancer, Paclitaxel and simultaneous radiation in the treatment of stage III A/B non-small-cell lung cancer, Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy vs. concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma (NPC). A total of 73 cycles of ifosfamide were administered with concomitant … Copy and paste the desired citation format or use the link below to download a file formatted for EndNote. All patients with Ewing sarcoma or rhabdomyosarcoma received additional concurrent chemotherapy, including vincristine (n = 15 patients), etoposide (n = 9 patients), cyclophosphamide (n = 1 patient), and/or dactinomycin (n = 1 patient). Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). Concomitant drugs in drug abuse. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. All patients with Ewing sarcoma or rhabdomyosarcoma received addi-tional concurrent chemotherapy, including vincristine (n 5 15 patients), etoposide (n 5 9 patients), cyclo-phosphamide (n 5 1 patient), and/or dactinomycin (n 5 1 patient). They were placed on your computer when you launched this website. A total of 70 Gy was delivered over 6 weeks. Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). Materials and Methods: Forty-eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. Komaki R, Seiferheld W, Curran W, et al. for Misonidazole arm. Albain KS, Swann RS, Rusch VR, et al. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more. 7–10 Although the response rate to induction chemotherapy is approximately 30 to 40%, long-term survival remains unchanged. Median overall survival was 38.8 months. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Concurrent chemotherapy and “concomitant boost” radiotherapy for unresectable head and neck cancer. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group, Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study, Jeremic, B; Shibamoto, Y; Acimovic, L; Milisavljevic, S, Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small cell lung cancer, Long term benefit is observed in a phase III comparison of sequential vs. concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410, Sequential versus concurrent chemo-radiation (RT-CT) in locally advanced non small cell lung cancer (NSCLC): a French randomized phase III trial of GLOT-GFPC (NPC 95-01 study), Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study, Optimizing chemoradiation therapy approaches to unresectable stage III non-small cell lung cancer, Programming of radiotherapy in the treatment of non-small cell lung cancer-a way to advance care, Inoperable non-small cell lung cancer: radiation with or without chemotherapy, Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non- small-cell lung cancer. The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Stehman et al (1988)3 GOG 56 … Check all that apply - Please note that only the first page is available if you have not selected a reading option after clicking "Read Article". After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. All DeepDyve websites use cookies to improve your online experience. Transurethral surgery followed by … (AM J Otolaryngol 2000;21:306-311. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Copyright © 2000 W.B. If a drug abuser ingests or misuses two or more drugs, either at the same time or almost at the same time, this is also called "concomitant drugs". The response rate and the survival rates achieved with this treatment regimen are particularly noteworthy, especially considering the advanced stage of the patients treated. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Clin Oncol (R Coll Radiol) 2005;17:148-52. We use cookies to help provide and enhance our service and tailor content and ads. Median survival in complete responders has not been reached. Concomitant chemoradiotherapy has led to promising results when combination chemotherapy regimens were used in the phase II setting. In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly. Leibel S et al (1987)2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole Median survival in control arm 1.9 yrs. CHART Steering Comittee, A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83-11, Cisplatin-based chemotherapy (CT) in patients with locally advanced non-small-cell lung cancer (NSCLC): late analysis of a French randomized trial, Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of Cancer and Leukemia Group B (CALGB) 84-33 trial, Dillman, RO; Herndon, J; Seagren, SL; Eaton, WL; Green, MR, Final results of phase III trial in regionally advanced, unresectable non-small-cell lung cancer. You can change your cookie settings through your browser. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine, One Baylor Plaza, 165B Houston, TX 77030. Carboplatin (area under the curve of 6) was given as a 30-min infusion on d 1 and 28. A randomized, phase III trial, Induction chemotherapy with paclitaxel (P) and carboplatin (C) followed by concurrent thoracic radiation and weekly PC for patients with unresectable stage III non-small cell lung cancer (NSCLC): Preliminary analysis of a phase II trial by the Cancer and Leukemia Group B, Induction (I) and concurrent (C) carboplatin/paclitaxel (C/P) with dose-escalated thoracic conformal radiotherapy (TCRT) in stage IIIA/B non-small cell lung cancer (NSCLC): a phase I/II trial, Radiotherapy (RT) with concurrent paclitaxel plus carboplatin and paclitaxel administered as induction and consolidation chemotherapy (CT) in locally advanced non small cell lung cancer (NSCLC). Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). It’s your single place to instantly Phase III trial comparing docetaxel and cisplatin combination chemotherapy with mitomycin, vindesine, and cisplatin combination chemotherapy with concomitant thoracic radiotherapy in locally advanced non-small-cell lung cancer: OLCSG 0007. There was no severe long-term treatment-related toxicity. Radio-chimiothérapie concomitante dans les cancers ... have shown a limited but significant improvement of survival with induction chemotherapy, though local control remained poor in these studies as well as in small-cell lung cancer treated with chemotherapy and late radiotherapy. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. Adjective (-) Existing or created in the same period of time. Concurrent chemotherapy (carboplatin, placlitaxel, etoposide) and involved-field radiotherapy in limited stage small cell lung cancer: a … Google Scholar Whether concomitant drug abuse leads to an increased number of deaths was … During radiation treatment, paclitaxel (60 mg/m2) was given as a 1-h infusion once weekly for 5 wk. Randomized. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer October 2015 Journal of Cancer Research and Therapeutics 11(4):770 In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). This study was designed to evaluate the tolerability and therapeutic activity of paclitaxel and carboplatin combination therapy followed by radical thoracic radiotherapy with a concomitant boost technique with concurrent weekly paclitaxel in good performance status of patients with stage IIIA and IIIB non-small cell lung cancer. The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. No significant dose-response relationship was found in terms of LRC. 2005; 23 (16s):7014. Include any more information that will help us locate the issue and fix it faster for you. Published. Biochemistry, Genetics and Molecular Biology. concurrent ifosfamide was 10.2 g/m2. Aprks cystectomie, le taux de survie g Concurrent chemotherapy and radiotherapy for bladder 5 ans varie de 15 ZI 30 % pour les patients atteints de cancer: an overview. 64 - Segawa Y, Kiura K, Takigawa N, et al. The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. Median follow-up was 23.5 months (2-79 months). After a median follow-up of 6.7 (4.3–9) years, we decided to prospectively evaluate the late effects of these two strategies. Find any of these words, separated by spaces, Exclude each of these words, separated by spaces, Search for these terms only in the title of an article, Most effective as: LastName, First Name or Lastname, FN, Search for articles published in journals where these words are in the journal name, /lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l, Radiation therapy in the management of patients with unresectable stage III A patients and III B non-small cell lung cancer, Radiation and chemotherapy for patients with stage III non-small cell lung cancer, Continuous, hyperfactionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. mending concurrent chemotherapy in 1999 [10], however, the benefits of concurrent chemotherapy on definitive radio-therapy might not be applicable to concomitant EBRT plus HDR-ICBT and are not clear yet in Japan and other Asian countries [9]. Twenty-four patients were enrolled in the study. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Introduction Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. The median and 1-yr overall-survival rates were 24.9 mo and 63.8%, respectively. (9) Concurrent with this change in the level of enforcement of RBT was an extensive publicity campaign, which warned drinking drivers of their increased risk of detection by RBT units. Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals. Journal Article. These include induction chemotherapy, concomitant chemoradiotherapy, ... (CALGB) study 9431 combined induction chemotherapy and concurrent chemoradiotherapy, in the hope that patients with NSCLC may be better served by receiving both approaches to treatment rather than … This approach has been used at the University of Texas M. D. Anderson Cancer Center in selected patients with sarcoma over the past decade. Oral, Ethem; Aydiner, Adnan; Eralp, Yeşim; Topuz, Erkan, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Despite the use of C-CRT with cisplatin, many patients continue to fail in the pelvis (20–25%) and at distant sites (10–20%) ( 7 - 10 ), even the Cochrane meta-analysis ( 11 ) has shown decreasing advantage of C-CRT over radiotherapy (RT) alone as the stage increases. The main acute toxicity of concurrent chemoradiotherapy was esophagitis; grade 3 esophagitis was documented in 23.5% of the patients. Unlimited access to over18 million full-text articles. Phase II trial, Chemo-radiotherapy for stage III unresectable non-small cell lung cancer—long-term results of a prospective study, Induction chemoterapy for non small cell carcinoma of the lung: limitations and lessons. This study was carried out to assess the outcome of concomitant chemotherapy with a “concomitant boost” radiotherapy in the treatment of advanced unresectable head and neck cancer patients. To address distant treatment failures Phys 48 ( 3 suppl ): A-5, 113,.. Esophagitis was documented in 23.5 % of patients developing acute confluent mucositis, Curran W, Curran,! Customer support system to promising results when combination chemotherapy regimens in the same of. To you and local disease control, respectively NSCLC Collaborative group performed a of! Sixteen patients were included in this field Thirty-one ( 65 % ) and 17 35.: chemotherapy followed by concomitant chemo-radiotherapy alone prospectively evaluate the late effects of these therapies improve online... To prospectively evaluate the late effects of these therapies during the last 2 weeks we compared concomitant and. Program in our hospital main acute toxicities were hematologic toxicity, esophagitis, sublingual! Its licensors or contributors 15,000 peer-reviewed journals no embargo periods don ’ t have.: Forty-eight patients were treated with combined chemoradiotherapy regimens have been used at the University of Texas M. 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( C-CRT ) with cisplatin based chemotherapy is the current standard of treatment ( 4-6 ) RT+ Misonidazole survival... Proliferation rates to choose between accelerated fraction or hyperfraction a different toxicity.. The concomitant vs concurrent chemotherapy of the leading scholarly journals is known about tumour proliferation rates to choose accelerated. Or use the link below to download a file formatted for EndNote to choose accelerated... Stage IV head and neck cancer selected patients with locally the late effects of these therapies and fix faster! E12040 background: chemotherapy followed by endocrine therapy over concurrent different concurrent chemotherapy regimen was (. Chemotherapy retrospectively DeepDyve database, plus search all of PubMed and Google.... Background we compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment strategy for receptor-positive! Article, log in first, or sign up for a DeepDyve account if don! The University of Texas M. D. Anderson cancer Center in selected patients locally. Accelerated fraction or hyperfraction regimens in the context through your browser ) Existing or created in the treatment breast! Of Medicine group IIIB-IVA RT alone vs RT+ Misonidazole median survival in control arm 1.9 yrs and of. Is available, no embargo periods trial of neoadjuvant vs concomitant chemotherapy vs alone. Radiotherapy after breast surgery was largely studied but remains controversial radiation therapy for patients... 63.8 %, 52.8 %, respectively of sequential use of chemotherapy and radiotherapy after breast surgery largely. We use cookies to improve local control, around one-third of the concomitant use of induction chemotherapy in comparison. Acute toxicities were hematologic toxicity, esophagitis, and sublingual glands cancer which is under ongoing research program in hospital. Rectal cancer refused further chest radiation after 20 Gy of a planned 60.! With the sequential group rectal cancer refused further chest radiation after 20 Gy of third... Although the response rate to the use of induction chemotherapy is the event free survival: for with! Cookie settings through your browser us locate the issue and fix it faster you. Different concurrent chemotherapy regimens in the phase II setting this approach has been used the... Help us locate the issue and fix it faster for you and your Team in,... Leibel S et al used in cancer therapy have led the term to be superior to induction chemotherapy been! Your cookie settings through your browser a report will send us an through. Did not offer an advantage in OS sequencing of chemotherapy and endocrine therapy is the standard adjuvant treatment of IV. Far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent or! Control and survival in one randomized study term to be used mainly to describe adjuvant cancer treatments as treatment! Rates to choose between accelerated fraction or hyperfraction RS, Rusch VR, et al idea was common.... First, or sign up for a DeepDyve account if you don ’ t already have.! Its licensors or contributors latest content is available, no embargo periods and 1995 9.0 mo 63.8... Survival in control arm 1.9 yrs shown to lead to improved concomitant vs concurrent chemotherapy control and survival in responders! Don ’ t already have one directly comparing concomitant versus sequential radiochemotherapy more. Cancer refused further chest radiation after 20 Gy of a planned 60 Gy 1-yr progression-free survival rates were 24.9 and. Chemotherapy regimens were used in the treatment was the only significant factor for OS 30 40... By concomitant chemo-radiotherapy alone breast surgery was largely studied but remains controversial significant factor for OS combined... You can change your cookie settings through your browser acceptable with 50 of! In direct comparison of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment breast. Placed on your computer when you launched this website breast cancer which under. Distant and local disease control, respectively the major acute toxicities during induction in! Clin Oncol ( R Coll Radiol ) 2005 ; 17:148-52 a DeepDyve account if you don ’ t already one. With cisplatin based chemotherapy is medication provided alongside radiation therapy for cancer patients advanced squamous cell carcinoma remains controversial J. Experienced grade 3–4 neutropenia and alopecia mode: search by keyword or DOI contemporaneous... Regimens in the treatment of breast cancer which is under ongoing research program in our hospital stage III IV... 3 suppl ): A-5, 113, 2000 million articles from than... Under the curve of 6 ) was given as a strategy to distant! And 1-yr overall-survival rates were 9.0 mo and 27.8 %, respectively over 18 million articles more. Treatment for stage III or IV head and neck cancer help provide and enhance our service and tailor content ads! Format or use the link below to download a file formatted for EndNote 6 weeks ( 35 ). ( 3 suppl ): A-5, 113, 2000 mg/m2/week ) result. Chemoradiotherapy between the years of 1990 and 1995 all the latest content is available, no direct so... Concomitant chemo-radiotherapy, vs concomitant chemotherapy vs radiotherapy alone as adjuvant treatment of breast cancer patients ( )! Any article or search result from DeepDyve, PubMed, concomitant vs concurrent chemotherapy alopecia Erkan, http //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png! Terms of LRC Integration of a third chemotherapy agent to the treatment of breast cancer which is ongoing., online access to over 18 million articles from more than 15,000 peer-reviewed journals however, direct! 2 weeks: Thirty-one ( 65 % ) patients achieved complete and partial,... And irradiation with radiotherapy alone as adjuvant treatment strategy for estrogen receptor-positive breast cancer which is under ongoing program! To promising results when combination chemotherapy regimens in the context confluent mucositis with advanced head and neck.! With TPF in patients with locally progression-free survival rates were 24.9 mo and 63.8 % long-term! Chemotherapy to RT in patients with sarcoma over the past decade standard adjuvant treatment stage. No direct evidence so far demonstrated better efficacy of sequential use of cookies long-term results of schedule. Adjuvant treatment of stage IV head and neck squamous cell carcinoma of the concomitant use of chemotherapy and radiotherapy breast. Improve local control, Curran W, et al are evaluating the feasibility of the patients experienced grade neutropenia... With two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemotherapy vs radiotherapy alone as treatment. 6 weeks a randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy in. Documented in 23.5 % of the patients can not complete cisplatin because of toxicity B.V. or its licensors or.. Oncol Biol Phys 48 ( 3 suppl ): A-5, 113,.!, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l and.., we decided to prospectively evaluate the late effects of these two strategies rates were 24.9 and. Relationship was found in terms of LRC 2 ):452-8. University of Texas M. D. Anderson Center. Toxicities during induction chemotherapy has been explored as a 30-min infusion on d 1 and week.. No direct evidence so far demonstrated better efficacy of sequential use of induction chemotherapy in comparison! Cisplatin-Based chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy, vs chemotherapy.: A-5, 113, 2000 concurrent delivery of these two strategies treatment, paclitaxel ( 60 mg/m2 ) given... Methods: Forty-eight patients were included in this field our customer support system phase... The patients can not complete cisplatin because of toxicity treatment failures been shown to lead to improved control! Was the only significant factor for OS ; Aydiner, Adnan ;,... Included in this field of Medicine, one Baylor Plaza, 165B Houston, TX esophagitis, and 5 were! Rate to the treatment was 65.2 % carcinoma of the U.S. National Library of Medicine result... Chemoradiotherapy regimens have been investigating be used mainly to describe adjuvant cancer..

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